Author

Zhong-Heng Zhang

2 papers indexed here

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Open access Oct 2026

Serum EV-enriched proteomics reveals host-response subtypes and molecular similarity to organ dysfunction phenotypes in sepsis

Sepsis is a heterogeneous syndrome characterized by dysregulated host responses and diverse patterns of organ dysfunction. This study aimed to characterize serum extracellular vesicle (EV)-enriched proteomic heterogeneity in sepsis and assess whether proteomic subtypes identified among Sepsis-only patients showed m...

Rui Ding, Shi-Han Zhang, Xin-Yan Liu et al. · Frontiers in Medicine · 0 citations

Review Open access Aug 2026

External validity limitations of randomized trials cited in adult critical care clinical practice guidelines: a systematic review of guidelines published from 2015 to 2020

Objective Clinical practice guidelines (CPGs) support evidence-informed decision-making, but the randomized controlled trials (RCTs) cited as supporting evidence may have restricted eligibility criteria and limited external validity for clinically complex populations. This study aimed to describe exclusion criteria and...

Wei Chen, Li Zhong, Cheng Zheng et al. · Frontiers in Medicine · 0 citations