Review
Open access
Sep 2026
Neuro-immune-bone axis in post-traumatic bone regeneration: temporal regulation, dysregulation mechanisms, and therapeutic implications
Post-traumatic bone regeneration extends beyond a mere osteogenic event to encompass a dynamic reparative cascade characterized by the coordinated interplay of inflammation, nerve reinnervation, angiogenesis, mesenchymal stem cell differentiation, and osteoblast-osteoclast coupling. While immune and neural regulation...
Zhong-Hua Wang, Hai-Jun Zhang
· Frontiers in Immunology · 0 citations