Identification of AHR, UACA, GCLM, and GSTZ1 as candidate genes associated with metabolic alterations in intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is the leading pathological cause of chronic low back pain, but reliable molecular indicators for grading degeneration severity remain scarce. The interplay between metabolic reprogramming (MR) and the immune microenvironment in IVDD pathogenesis remains poorly characterized....