Sep 2026
Virus-inspired disulfide engineering enables gene delivery via remodeling of cellular uptake and organ distribution.
Efficient cytosolic delivery remains a central challenge in the clinical translation of gene therapeutics. Inspired by viral strategies, we explored disulfide chemistry as a structural lever to enhance cellular uptake and intracellular trafficking. We systematically incorporated disulfide moieties into the poly(β-amino...
Liang Yao, Jia-Hao Liu, Run-Qi Zhu et al.
· Journal of Controlled Releas... · 0 citations