Zhong-Wei Xiong

Macrophage immunometabolism in osteoporosis: an emerging regulatory axis linking metabolic–polarization coupling to therapeutic targets

Osteoporosis has long been understood, and treated, as an imbalance between osteoblastic bone formation and osteoclastic resorption. Yet many patients continue to lose bone, pointing to upstream regulators of the remodeling unit that remain poorly defined. Macrophages are developmentally continuous with osteoclasts and...