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Zhong-Yi Jiang

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Open access Sep 2026

Structural insights into ligand-induced CARD assembly in inflammatory caspases

Abstract Non-canonical inflammatory caspases detect cytosolic lipopolysaccharide (LPS) through its caspase activation and recruitment domain (CARD), yet how ligand binding drives higher-order CARD assembly remains poorly understood. Here, we identify CBM7, a minimal SERPINB1-derived peptide, that induces caspase-4 CARD...

Jae U. Jung, Zhong-Yi Jiang, Junbae Park et al. · 0 citations

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