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Author

Zhong-Yuan Bai

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Open access Oct 2026

Perineural invasion is associated with an aggressive phenotype and reduced in vitro capecitabine sensitivity in colorectal cancer

Perineural invasion (PNI) is an aggressive biological feature of colorectal cancer (CRC) driven by active crosstalk between tumor cells, Schwann cells, and the neural microenvironment. Although PNI is associated with recurrence, distant metastasis, and chemoresistance, its pathologic diagnosis is constrained by sam...

Shu-Zhe Yang, Zhong-Yuan Bai, Ya-Nan Li et al. · 0 citations
Oct 2026

Reproducible and Interpretable H&E-based Histopathological Subtypes of Non-metastatic Lymph Nodes Refine Risk Stratification in Colorectal Cancer.

Lymph node status is fundamental for staging, prognostic assessment, and treatment decision-making in colorectal cancer (CRC); however, current pathological evaluation largely focuses on metastatic involvement and overlooks the biological heterogeneity of non-metastatic lymph nodes (LNs). Here, we developed a reproduci...

Zhen Zhang, Yue-Yang Zhang, Xu Liu et al. · 0 citations

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