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Zhongyue Zhang

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#artificial intelligence Preprint Sep 2026

Does Learning Protein Folding Generalize to Broader Reasoning?

Large language models rely heavily on human text, which often conveys surface answers rather than the spatial and structural logic behind them. Protein folding is a natural testbed, because one solved structure yields thousands of exactly checkable spatial and topological statements. We ask: can learning to fold protei...

Yong Liu, Zhan-Peng Shi, Yi-Zhou Dang et al. · 0 citations
Jul 2026

Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design

AAMFM, an Antigen-specific Antibody Multimodal Foundation Model that learns unified representations of antibody sequences and structures conditioned on antigen context, achieves state-of-the-art performance in functional antibody design, revealing its potential for antigen-specific antibody engineering.

Xiaoliang Shi, Zichen Wang, Runze Ma et al. · 0 citations

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