Author

Zhonghua Li

3 papers indexed here

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2026

Huanglian Jiedu decoction ameliorates Alzheimer’s disease by regulating calcium homeostasis via mitochondria-associated endoplasmic reticulum membranes

Objective(s): Huanglian Jiedu decoction (HLJDD), a classic traditional Chinese medicine formula, is investigated for its protective effects against Alzheimer’s disease (AD). This study explored its mechanism in an AD cell model, focusing on calcium ion (Ca²⁺) homeostasis regulation via mitochondria-associated endoplasm...

Yong Yuan, Zhong-Hua Li, Rui-Fang Wang et al. · Iranian Journal of Basic Med... · 0 citations

Open access Sep 2026

Discovery of a novel natural USP25 inhibitor via an integrated deep learning-guided screening strategy with molecular dynamics validation.

An integrated workflow coupling AI-based activity prediction and molecular docking to mine natural products as novel USP25 inhibitors is established, serves as an economical and efficient substitute for conventional high-throughput screening and creates a robust technical paradigm for early-stage drug discovery.

Zhong-Hua Li, Zhen-Zhen Wang, Zhen-Zhen Liu · European journal of medicina... · 0 citations

Aug 2026

Deep learning-driven discovery and optimization of natural LSD1 inhibitors for the treatment of Alzheimer's disease.

This study provides a generalized DTA tool for early-stage drug development, and identifies S3 as a novel LSD1 inhibitor with potent anti-AD efficacy, by addressing unmet demands for AI-assisted anti-AD lead discovery.

Zhong-Hua Li, Tiancheng Sun, M. Han et al. · Bioorganic chemistry (Print) · 0 citations