Genetic landscape features associated with PD-L1 expression status in advanced lung adenocarcinoma: a targeted sequencing analysis
This study delineates distinct genomic landscapes associated with PD-L1 expression, suggesting PD-L1-positive status is linked to an immune-active, kinase-signaling-driven phenotype with mutually exclusive drivers, and PD-L1-negative status correlates with a more immunosuppressive, co-mutation-prone, metabolism-oriente...