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Zhongshan Shi

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Jul 2026

STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease

Mechanistically, it was found that phosphorylated STAT6 (pSTAT6) enhanced autophagy, which reduced the burden of senescent microglia and thereby ameliorated CSVD-induced VCI, providing insights into the potential of targeting the STAT6 pathway in VCI associated with CSVD.

Xiaolu Liu, Qing Liu, Jingwen Yang et al. · 0 citations

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