Author

Zhuorong Li

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Open access Aug 2026

Targeting host lipogenesis with a diarylamide inhibitor disrupts SARS-CoV-2 replication

Summary The vulnerability of direct-acting antivirals to resistance has motivated interest in host-directed strategies that target conserved cellular pathways essential for viral replication. Here, we report a diarylamide molecule, compound 10 (compd. 10), which inhibits SARS-CoV-2 more potently than the parent clofoct...

Xintian Zhang, Tingfu Du, Yong-Jian Wang et al. · iScience · 0 citations

Open access Jul 2026

Combined therapy with ALK inhibitors and a novel EGFR-targeting antibody‒drug conjugate as a strategy for ALK-rearranged non-small cell lung cancers.

Combinatorial strategies targeting distinct signaling pathways may overcome the limitations of single-agent targeted therapies and demonstrate the synergistic antitumor activity of ALK inhibitor plus LR004-VC-MMAE against ALK-rearranged, EGFR-high NSCLC, providing a mechanistic rationale for further clinical developmen...

Lan-wen Zhang, Xiaofan Wu, Jing-Fei Gao et al. · Oncogenesis · 0 citations