Mechanistic Interplay Between Biomechanical Signaling and Epigenetic Regulation: Targeted Therapy Against Tumor Development and Malignant Progression.
An aberrant mechanical microenvironment is a major driver of malignant tumor progression. Its effects are not limited to the immediate regulation of tumor cell behavior. Through mechanotransduction-mediated epigenetic remodeling, external physical cues can also be converted into persistent malignant programs. Mechanica...