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Zi-Cheng Zhao

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Review Open access Oct 2026

Targeting TEAD in cancers: paralog-specific biology, resistance and therapeutic opportunities

Examination of TEA domain transcription factors TEAD molecular architecture, physiological functions and paralog-specific biology, together with canonical regulation by NF2/Merlin and the Hippo kinase cascade and non-canonical inputs from mechanical cues, oncogenic signaling, metabolism and hypoxia, suggests the therap...

Jia-Lin Wu, Fu-Da Xie, Bo-Nan Chen et al. · 0 citations

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