Open access
Aug 2026
Beyond Respiration: Heme A Synthase (CtaA) Orchestrates Hydrogen Sulfide Production and Virulence via Metabolic Reprogramming in Staphylococcus aureus
Endogenous hydrogen sulfide (H2S) serves as a pivotal gasotransmitter conferring antimicrobial resistance and shielding bacteria from oxidative stress. While cystathionine γ-lyase (CSE)-dependent H2S production is critical for Staphylococcus aureus survival, the upstream regulatory nodes linking metabolic status to H2S...
Jiahui Li, Mu He, Wanwan Hou et al.
· bioRxiv · 0 citations