KLF4 is associated with perioperative neurocognitive disorder and SMAD7-linked oxidative stress and ferroptosis-related signaling.
Perioperative neurocognitive disorder (PND) is a common complication after anesthesia and surgery, particularly in older individuals, and is associated with oxidative stress and ferroptosis. Krüppel-like factor 4 (KLF4) has been implicated in neuronal injury, but its role in PND remains unclear. Using a mouse model of...