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Author

Zi-Han Wang

2 papers indexed here

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Open access Oct 2026

TIA1 is required for microglial activation in tauopathy.

The RNA-binding protein T cell intracellular antigen-1 (TIA1) regulates cellular stress responses and tau pathology, key contributors to the pathophysiology of tauopathies, including Alzheimer's disease (AD). TIA1 acts in peripheral monocytes to inhibit inflammation, but its function in central microglia, critical to n...

C. J. Webber, S. V. D. van der Spek, A. L. Cruz et al. · 0 citations
Open access Oct 2026

Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.

Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present a temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mas...

Wei-Wei Lin, S. Phanse, S. V. D. van der Spek et al. · 0 citations

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