Zi-Han Wang

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α‑Synuclein Phase Separation

The Parkinson’s disease-related protein α-synuclein can form solid amyloid fibrils through liquid–liquid phase separation (LLPS) and liquid-to-solid phase transition. The most deleterious familial mutation E46K has recently been shown to enhance α-synuclein LLPS and subsequent solidification; yet, the precise mechanism...