KAT5/TIP60 orchestrates H4K16 and H2A.Z acetylation to drive the gonocyte-to-spermatogonia transition.
Spermatogenesis begins with the gonocyte-to-spermatogonia transition (GST) during the perinatal window, yet how chromatin regulation orchestrates this developmental transition remains elusive. Transcriptomic analysis identified histone acetylation as a significantly enriched pathway during the GST, and immunofluorescen...