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Author

Zi-Hui Gao

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Review Sep 2026

Damage-associated molecular patterns in skeletal muscle: a double-edged sword - from sterile inflammation initiation to precision targeted therapeutic strategies.

Skeletal muscle repair after injury depends on a tightly coordinated cascade of inflammatory and regenerative responses. Damage-associated molecular patterns (DAMPs) link tissue damage to innate immune activation, but their effects are highly context dependent. This review summarizes the major cellular sources of DAMPs...

Zi-Hui Gao, Xia Li, Ya-Nan Ji et al. · 0 citations
Review Aug 2026

The dual role of cell death in skeletal muscle homeostasis and disease: Mechanisms and therapeutic targeting.

The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.

Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al. · 4 citations
Aug 2026

Tectorigenin protects against muscle atrophy from in vitro nutrient deprivation and in vivo denervation by activating the AMPK/SIRT1/PGC-1α pathway.

BACKGROUND AND PURPOSE The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...

Boya Liu, Fei Xue, Xingxing Fang et al. · 2 citations

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