Tumor microenvironment-responsive micelles for mitochondrial copper depletion to enhance photodynamic therapy.
Triple-negative breast cancer (TNBC) exhibits aberrant copper accumulation that promotes tumor progression and metastasis. Targeting copper homeostasis, particularly at the mitochondrial level, represents a promising yet underexplored therapeutic strategy. Herein, a mitochondria-targeted nano-micellar system Ce6-TPP@PS...