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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Zimu Yu

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Open access Sep 2026

From single-sequence structure prediction to protein fitness landscape through a composable, epistasis-aware mutation atlas

Mapping the multi-mutant fitness landscape is vital to protein engineering, but is challenging due to the vast combinatorial sequence space awaiting exploration. A central difficulty lies in the accurate and efficient modeling of non-additive epistatic effects among individual mutations, which partially arise from the...

Wei-Zhe Wang, Zi-Mu Yu, En-Di Yang et al. · 0 citations
Open access Aug 2026

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

It is demonstrated that CMA activity is downregulated in nucleus pulposus cells from IDD patients and IL‐1β‐induced rat intervertebral disc cell models, causing cytoplasmic accumulation of a novel CMA substrate, Midnolin (MIDN).

Xianglong Chen, Hai-Yang Gao, Wang Wu et al. · 0 citations

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