Author

Ziqi Pan

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Open access Sep 2026

SingPro 2.0: a proteomics-centric knowledge base for single-cell multimodal profiling.

Protein-inclusive single-cell multimodal profiling has emerged as a transformative strategy for resolving cellular heterogeneity by jointly measuring proteins and complementary molecular features in the same cells. The resulting protein-inclusive datasets are increasingly used to characterize cellular states, construct...

Yuan Zhou, Jian-Nan Deng, Zi-Jie Zhu et al. · Nucleic Acids Research · 0 citations

Aug 2026

Accurate Identification of Covalently Ligandable Cysteines Using CCSite.

CCSite is presented, a protein language model-based framework for discovering covalently ligandable cysteines from protein sequences that uniquely integrates low-rank adaptation of ESM Cambrian with a cysteine-centered encoder-decoder module to capture local microenvironment features and long-range contextual informati...

Yan-Lin Ren, Min-Jie Mou, Yi-Miao Zhu et al. · Journal of Medicinal Chemist... · 0 citations