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Open access Sep 2026

Lysophosphatidylcholine-induced macrophage polarization imbalance and functional dysregulation in immune thrombocytopenia.

BACKGROUND The pathogenesis of immune thrombocytopenia (ITP) involves platelet destruction driven by immune dysregulation, notably macrophage dysfunction. Lysophosphatidylcholine (LPC), a class of bioactive lipid, can modulate inflammation and immunity. This study aimed to determine whether LPC (16:0/0:0) reprograms ma...

Nan Jiang, Zi Sheng, Shao-Qiu Leng et al. · 0 citations

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