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Open access Sep 2026

Limonin ameliorates hyperuricemia-induced cognitive impairment through modulation of microglial HIF-1α-driven neuroinflammation.

BACKGROUND Hyperuricemia (HUA), a highly prevalent metabolic disorder, is increasingly linked to cognitive impairment. Limonin (LIM), a natural compound with anti-inflammatory and neuroprotective properties, has the therapeutic benefits, but its underlying mechanisms remain unclear. PURPOSE This study aimed to invest...

Jie Chen, De-Xian Li, Xiao-Hu Chen et al. · 0 citations
Open access 2026

Fabrication and characterization of rutin-loaded liquid crystalline nanoparticles with in vitro anti-inflammatory and antitumor activities

ABSTRACT A rutin-loaded liquid crystalline nanoparticle (R-LCNP) formulation was developed using glyceryl monooleate and Poloxamer 407 by high-pressure homogenization to improve the solubility and biological performance of rutin. The optimized R-LCNP-2 dispersion showed a mean particle size of 176.1 ± 4.5 nm, a polydis...

Li-Sha You, Ningning Li, Zi-Wei Li · 0 citations

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