Author

Zi-Xuan Chen

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Open access Sep 2026

Triple-coupling of genomic potential, metabolite diversity, and microbial community optimization drives Bacillus velezensis DH18-mediated resistance to Fusarium root rot and growth promotion in strawberry

ABSTRACT Fusarium oxysporum-induced root rot severely threatens strawberry production, necessitating effective mitigation strategies. Beneficial microorganisms that simultaneously suppress disease and promote plant growth offer promising solutions, yet their multiscale mechanisms remain poorly understood. Here, a dual-...

Wei Cheng, Jia-Jia Hua, Yi-Ping Chen et al. · Microbiology spectrum · 0 citations

Sep 2026

Dual GPX4/PARP inhibitor YHD-26 exerts potent antitumor activity against triple-negative breast cancer via ferroptosis and DNA damage synergy.

Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, associated with poor prognosis and frequent drug resistance. Ferroptosis refers to an iron-dependent form of non-apoptotic cell death triggered by lipid peroxidation, offering a promising strategy to overcome this resistance. Her...

Hong-Lei Bao, Yu-Pei Lai, Xi Zhao et al. · Biochemical Pharmacology · 0 citations

Sep 2026

Conformation-driven design, synthesis and biological evaluation of novel PAK1 inhibitors that downregulate PD-L1 for triple-negative breast cancer therapy.

The design, synthesis, and biological evaluation of a series of novel PAK1 inhibitors guided by a conformation-driven optimization strategy establish ZMF-28 as a promising therapeutic candidate for TNBC and highlight the value of conformation-guided design in kinase inhibitor discovery.

Hong-Lei Bao, Yu-Pei Lai, Xi Zhao et al. · European journal of medicina... · 0 citations