Author

Zi-Xuan Chen

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Open access Sep 2026

Therapeutic Potential of the Deubiquitinase BRCC3 in Attenuating Ischemic Myocardial Injury and Ventricular Remodeling

The transforming growth factor-β1 (TGF-β1)/Smad3 pathway drives DNA damage, necrosis, and ventricular remodeling following acute myocardial infarction (AMI); however, effective therapies targeting this cascade remain limited. Here, we investigated the role of the deubiquitinating enzyme BRCA1/BRCA2-containing complex s...

De-Shan Yao, Si-Chuan Wang, Ru-Jun Li et al. · Research · 0 citations

Review Open access Aug 2026

Microglial immunosurveillance after ischemic stroke: dynamic phenotypes, neurovascular interactions, and therapeutic opportunities

Ischemic stroke induces complex neuroimmune responses that extend beyond acute neuronal injury and involve dynamic interactions among microglia, the neurovascular unit, and peripheral immune cells. Microglia rapidly transition from homeostatic surveillance to damage sensing, cytokine production, phagocytic clearance, a...

Yingshi Bao, Zi-Xuan Chen, Xian Jia · Frontiers in Immunology · 0 citations