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Zi-Xuan Shen

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Review Open access Oct 2026

Effects of intensive insulin therapy combined with non-insulin antihyperglycemic agents on glycemic control, variability, and metabolic outcomes in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Intensive insulin therapy (IIT) induces clinical remission in newly diagnosed or poorly controlled type 2 diabetes mellitus (T2DM), but is limited by hypoglycemia risk and weight gain. Combining IIT with non-insulin antihyperglycemic agents may mitigate these drawbacks while improving glycemic variability....

Zi-Xuan Shen, Jia-Wei Li, Zi-Yun Zhao et al. · 0 citations

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