Effects of intensive insulin therapy combined with non-insulin antihyperglycemic agents on glycemic control, variability, and metabolic outcomes in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Intensive insulin therapy (IIT) induces clinical remission in newly diagnosed or poorly controlled type 2 diabetes mellitus (T2DM), but is limited by hypoglycemia risk and weight gain. Combining IIT with non-insulin antihyperglycemic agents may mitigate these drawbacks while improving glycemic variability....