Author

Zi-Yan Shen

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Open access Aug 2026

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, its role in renal fibrosis remains unclear. In the...

Shi-Qi Lv, Zi-Yan Shen, Yu-Lu Gu et al. · Molecular Biomedicine · 0 citations

Open access Aug 2026

Causal relationships between gut microbiota, metabolites, and chronic kidney disease: a two-step, two-sample Mendelian randomization study

Genetic evidence is provided that gut microbiota influence CKD risk partially through circulating metabolites, highlighting the gut microbiota–metabolite–CKD axis as a potential therapeutic target.

Ying Qian, Yue Yang, Zi-Yan Shen et al. · Clinical Kidney Journal · 0 citations