Review
Open access
Aug 2026
Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation
The conceptual framework of metabolite-driven protein modifications is summarized, established marks are compared, and remaining questions surrounding pyruvylation chemistry, enzyme and substrate specificity, reader mechanisms, compartmentalization, detection strategies, physiological relevance, and potential immunopha...
Zi-Ye Zhang, Ming-Ze Xu, Sen Zhang et al.
· Frontiers in Immunology · 0 citations