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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zi-Ye Zhu

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Sep 2026

Auto-S-fatty acylation of PKM2 regulates its tetramerization and glycolytic metabolism in cancer cells.

Cancer cells rely on aerobic glycolysis to fuel proliferation, yet how lipid metabolism dynamically regulates glycolysis remains incompletely understood. Here, we identify pyruvate kinase M2 (PKM2) is regulated by auto-S-fatty acylation. Using bioorthogonal chemical reporters, we demonstrate that PKM2 is S-fatty acylat...

Chen Miao, Zhen Wang, Ke-Lin Li et al. · 0 citations

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