Zi-Ying Yan

Ferret Glandular Myoepithelial Cells Are Multipotent Airway Progenitors with a Secretory Lineage Bias.

KRT7 CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

Keratin 7 (KRT7) is expressed in simple and ductal epithelia and is associated with epithelial plasticity during development, injury, and disease. However, the in vivo fate and regenerative behavior of KRT7⁺ cells remain poorly defined because lineage-tracing models are lacking in species that closely recapitulate huma...

KRT7 Marks an Airway Glandular Ductal Stem Cell Population That Supports Multilineage Development and Regeneration

The KRT7⁺ ductal niche is identified as a critical progenitor reservoir for airway development, homeostasis, and regeneration, with implications for cystic fibrosis therapies.

TBC1D23-AAVR interaction drives endosome-to-TGN trafficking required for rAAV transduction.

TBC1D23 is defined as a receptor-proximal trafficking module that couples AAV-AAVR engagement to vesicle transport, revealing a missing core regulatory step in AAV retrograde transport that is essential for productive rAAV transduction.