EC exerts significant protective effects against MAFLD by upregulating the MFN2/ERMIT2 axis and suppressing the PERK, eIF2α, and ATF4 ERS pathway, suggesting a restorative effect on calcium handling, maintains ER homeostasis, and reduces hepatocyte injury, highlighting EC as a promising therapeutic candidate for MAFLD.
Qing-Xuan He, Meng-Zhen Wang, Xu Wang et al.· Endocrine, Metabolic & Immun...· 0 citations
Th17-related genes TLR2, TROAP, AURKB, and TK1 serve as high-performance diagnostic biomarkers for autoimmune thyroiditis and offer novel molecular targets for targeted therapies.
Zi-Yu Liu, Ming Ren, Jia-Yun Li et al.· Combinatorial chemistry & hi...· 0 citations
These findings bridge the gap between metabolic lipotoxicity and epigenetic regulation, suggesting that lactylation acts as a critical driver in NAFLD pathogenesis.
Qing-Xuan He, Xu Wang, Peng-Fei Wang et al.· Endocrine, Metabolic & Immun...· 0 citations
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