Author

Zi-Yu Wang

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Review Open access Jul 2026

Artificial intelligence for dental caries diagnosis: translating algorithms to clinical practice

This review synthesizes the full development pipeline of AI for caries diagnosis—from data curation and ground-truth construction to model design, validation, and clinical deployment and outlines a roadmap for translating AI innovation into trustworthy, equitable, and clinically meaningful decision-support systems capa...

Zi-Yu Wang, Zixuan Zhu, Ti Jiang et al. · Frontiers in Medicine · 0 citations

Sep 2026

Metformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration.

Intervertebral disc degeneration (IDD) is associated with the loss of nucleus pulposus derived mesenchymal stem cell (NP-MSC) function, but the contribution of the mitochondrial unfolded protein response (UPRmt) to this process is not well understood. We found that SIRT1 and the UPRmt-related proteins HSP60, ATF5, and...

Shan-Zhong Shao, Zhi-Wei Huang, Jin-Run Liu et al. · Free Radical Biology & Medic... · 0 citations