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Zi-Zhao Yang

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Aug 2026

Multi-Omics-Driven Network Pharmacology and Experimental Validation Reveal the Molecular Mechanism of Bupi Yichang Pill in Treating Ulcerative Colitis Through Regulation of the PI3K/Akt/IKK/NF-κB Pathway.

Multi-omics analysis revealed that BYP restored gut microbiota dysbiosis, ameliorated bile acid and amino acid metabolism, and modulated the expression of inflammation- and barrier-related genes, providing both a mechanistic basis and pharmacological rationale for its traditional clinical use in UC management.

Yunlu Zou, Zi-Zhao Yang, Jiatong Liu et al. · 1 citation

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