Ziane-Chaouche Lydia

TREM2 blockade reprograms HER2 CAR macrophages toward inflammatory phagocytes in breast cancer models

Tumor-associated macrophages (TAMs) are key regulators of the breast tumor microenvironment and often display immunosuppressive functions that limit cellular immunotherapy efficacy. Triggering receptor expressed on myeloid cells 2 (TREM2) has emerged as a modulator of myeloid cell activity and a potential target to e...