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Zihe Zhou

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Review Open access Aug 2026

How Cancer Cells Exploit Unfolded Protein Response Signaling for Survival, Metastasis, and Therapy Resistance

This review summarizes how the three canonical UPR branches establish a persistent adaptive state under chronic ER stress and discusses the molecular mechanisms by which UPR signaling maintains proteostasis, reprograms cellular metabolism, alleviates oxidative stress, and coordinates autophagy.

Zihe Zhou · 0 citations

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