Development and External Validation of an M2 Macrophage–Related Prognostic Signature in Breast Cancer Using Multi-Omics Data and Machine Learning
Yan-Zhan Liu, Ye-Long Liu, Hong-Yan Wang et al.
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Open access
Oct 2026
Development and External Validation of an M2 Macrophage–Related Prognostic Signature in Breast Cancer Using Multi-Omics Data and Machine Learning
Purpose Tumor-associated macrophages (TAMs), particularly the M2-like phenotype, are central regulators of breast cancer progression; however, clinically applicable models capturing their functional heterogeneity and biological mechanisms remain limited. Patients and Methods We integrated single-cell RNA sequencing, sp...
Yan-Zhan Liu, Ye-Long Liu, Hong-Yan Wang et al.
· Breast Cancer · 0 citations
Open access
Aug 2026
Exploration of the regulatory mechanism of PD-L1 expression in pMMR AGS gastric cancer cell by cytotoxic drugs and anti-angiogenic drugs
It is demonstrated that cytotoxic drugs and the anti-angiogenic drug(apatinib) effectively inhibited the proliferation of pMMR-type AGS gastric cancer cells and may also have the potential to upregulate PD-L1 mRNA and protein expression in pMMR-type AGS gastric cancer cells.
Jinming Li, M. Da, Xue-Ying Zhou et al.
· Scientific Reports · 0 citations