Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP dimerization modes, the molecular basis underl...
Ye-Qing Du, Tai-Ping Zhou, Wen-Ya Tian et al.· Journal of the American Chem...· 0 citations
Unlike the antimicrobial darobactin, aphotorhaptin A appears to lack antibacterial activity but modulates nematode development, and this activity requires the ether crosslink and the N-terminal acetyl group in the hexapeptide scaffold.
Suze Ma, Ru Li, Xiang-Yang Gao et al.· Proceedings of the National...· 0 citations
PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.
Yan Gao, Kai Jiang, Yu-Han Dai et al.· Journal of the American Chem...· 0 citations
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