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Open access Aug 2026

PhaseOM: an integrated multi-task framework for phase separation analysis and key residue detection.

INTRODUCTION Liquid-liquid phase separation (LLPS) drives cellular organization through scaffold proteins that initiate condensate formation and client proteins that partition into them. Current computational tools lack precision in differentiating these functional classes and identifying key intrinsically disordered r...

Liping Xu, Sheng-Ming Zhou, Zixu Ran et al. · 0 citations
Jul 2026

Language Model-Enhanced Geometric Learning for Metalloprotein Pathogenic Mutations.

MetalDiagnosis is proposed, a deep learning framework that integrates an improved equivariant graph neural network with a pre-trained protein language model to predict disease-associated mutation sites in metal-binding proteins and employs a sliding-window strategy to extract deep contextual semantic information from t...

Xudong Guo, Runchang Jia, Heyun Sun et al. · 0 citations

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