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Ziye Chen

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Open access Jul 2026

Comprehensive Transcriptomic and Proteomic Profiling of CILD40 with Novel Compound Heterozygous Mutations of DNAH9

Plasma proteomic analysis of patients with CILD40 identified significant enrichment of pathways related to platelet activation, complement and coagulation cascades and differential signatures in CILD40, highlighting the potential of plasma proteomics for understanding distinct pathogenic mechanisms across PCD subtypes.

Siming Kong, Mingshuo Wang, Xuedong Wang et al. · 0 citations
Jul 2026

Synergistic oncogenesis in human cholangiocytes: IDH1 mutation and the biliary microenvironment to drive early transformation and a targetable metabolic dependency in patient-derived organoids.

A novel, physiologically relevant in vitro model that recapitulates the synergistic oncogenesis driven by IDH1 R132C mutation and microenvironmental stress in early CCA is established and provides a preclinical platform for identifying and testing interceptive strategies aimed at reversing or halting early cholangiocarcinogenesis in high-risk settings.

Ziye Chen, Qingru Song, Jinxin Wang et al. · 0 citations