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Author

Ziyuan Zhang

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Jul 2026

Targeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction.

It is demonstrated that CMA is suppressed in the aging heart, which promotes collagen overproduction in fibroblasts, whereas enhancing CMA activity ameliorates fibrosis and diastolic dysfunction and establishes a BHB-HCAR2-CMA-SHMT2 regulatory axis as a critical mechanism driving aging-related cardiac fibrosis.

Ziwen Wang, Ziyuan Zhang, Zheng Ping et al. · 0 citations

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