Author

Ziyue Yuan

3 papers indexed here

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Aug 2026

Repurposing butoconazole as a GRP78 substrate-binding domain (SBD) inhibitor to induce endoplasmic reticulum stress-mediated apoptosis in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is aggressive with limited therapies and poor prognosis. Butoconazole, a clinical topical imidazole antifungal for vulvovaginal candidiasis, has not previously been investigated for TNBC treatment. Here, we repurposed butoconazole as a novel allosteric inhibitor of glucose-regulated...

Yaowen Song, Ziyue Yuan, Zhi-Jia Li et al. · Bioorganic chemistry (Print) · 0 citations

Review Open access Aug 2026

Harnessing autophagy-dependent ferroptosis: Mechanisms and therapeutic opportunities in human diseases.

Ferroptosis represents an iron-dependent form of cell death driven by lipid peroxidation. Autophagy is an evolutionarily conserved lysosomal degradation pathway, and its dysregulation may trigger or facilitate cell death. Autophagy-dependent ferroptosis (ADF) denotes a specific subtype of ferroptosis executed via selec...

Xiao Cui, Xinzhu Dong, Yang Li et al. · Pharmacological Research · 0 citations

Review Open access Jul 2026

Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies

Lysosomes serve as central degradative hubs in cells, playing critical roles in maintaining protein homeostasis, clearing damaged organelles, and regulating metabolic signaling. Tumor cells heavily rely on lysosomal functions during proliferation, invasion, and drug resistance, a dependency that concurrently endows the...

Yang Li, Jiajie Feng, Xinzhu Dong et al. · Biomarker Research · 0 citations