Preprint
Aug 2026
Testing for subgroup treatment effect consistency in the Cox model
An overall treatment effect in a clinical trial may inadequately represent particular patient subgroups, creating uncertainty about whether a population-level efficacy conclusion can legitimately be transferred to them. Conventional interaction tests only investigate whether subgroup-specific treatment effects are exac...
Lukas Koletzko, Holger Dette, B. Bornkamp et al.
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