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Author

Zoltán Kis

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2 papers indexed here

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Open access Sep 2026

Integrated in vitro transcription and oligo-dT affinity chromatography enable multi-cycle reagent recycling for mRNA manufacturing

A platform process underpins the manufacturing of RNA-based vaccines and therapeutics. However, it remains constrained by high operational expenditures from costly reagents, inefficient raw-material utilization, and extensive purification. We report an integrated sequential-batch in vitro transcription (IVT)-oligo-dT c...

Adithya Nair, Ji-Xin Qu, Manoj Pohare et al. · 0 citations
Review Open access Sep 2026

In vitro transcription for RNA vaccines and therapeutics: a quality-by-design perspective on manufacturability.

In vitro transcription (IVT) is the core unit operation for the synthesis of the drug substance (DS) in RNA-based vaccines and therapeutics. As RNA medicines mature into a clinically validated product class, the central challenge is shifting from clinical feasibility to manufacturability. This review reframes IVT as a...

Adithya Nair, Zoltán Kis · 0 citations

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