Zoltán Wiener

Fibroblasts selectively modulate immune cell-derived cytokine effects on tumor cells in colorectal cancer

Introduction Colorectal cancer (CRC) is a heterogeneous malignancy and a major cause of cancer-related mortality worldwide. Cancer-associated fibroblasts (CAFs) accumulate in tumors and correlate with poor patient survival, suggesting a central role in immune regulation. Patient-derived organoids (PDO) maintain the int...