Open access
Sep 2026
PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction
Multiple myeloma (MM) is a neoplastic disorder of plasma cells within the hematopoietic system and is characterized by osteolytic lesions. Despite significant advances, the molecular underpinnings of myeloma and its associated bone pathologies remain elusive, and there is an unmet need for effective targeted therap...
Rui Liu, Ya-Zhu Huang, Zhi-Hong Fang et al.
· Cell Death & Disease · 0 citations