Background Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (DA) neurons and aberrant α-synuclein (α-syn) aggregation, yet disease-modifying therapies that simultaneously retard neurodegeneration and foster regeneration remain lacking. Methods In this study, we isolated extrace...
Zhen Qi, Xiao-Wen Li, Xiao Jin et al.· bioRxiv· 0 citations
This article adopts a multi-dimensional integration perspective to systematically summarize innovative breakthroughs in the construction of cardiac organoids through intelligent biomanufacturing, neuro-vascular-immune co-construction, and single-cell omics.
Heart failure (HF), the terminal stage of most cardiovascular diseases, remains a major global health burden with limited therapeutic options that do not fully achieve myocardial repair or functional recovery. Extracellular vesicles (EVs), nanoscale membrane-bound particles released by cells, have been increasingly rec...
Tingting Li, Jin Yang, Xinyue Ding et al.· Frontiers in Pharmacology· 0 citations
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