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Author

Zongnan Lyu

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Sep 2026

AdvLIF: An Adversarially and Physics-Inspired Framework for Virtual Staining and Nucleus Segmentation.

AdvLIF is introduced, an adversarially regularized and physics-inspired framework for jointly generating H&E-like and complementary auxiliary modalities from IHC images and segmenting nuclei and achieves superior quantitative fidelity, exemplified by the lowest error on the IHC Quantification Difference metric.

Qi Yu, Chun-Xue Shao, Ren-Yu Yang et al. · 0 citations
Open access Jul 2026

Systematic Evaluation of Competing Brain Transcriptomic Representations Reveals Reciprocal Patterns Across Heterogeneous Contexts

Two representations of cross-context brain transcriptomic organization are compared: a transcriptome-wide global-axis model and a low-dimensional reciprocal model, motivating a low-dimensional reciprocal representation as an exploratory framework while emphasizing context dependence, cohort dependence, and heterogeneit...

Zongnan Lyu, Chunxue Shao, Qi Yu et al. · 0 citations

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