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Author

Zoya Qaiyum

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Open access Sep 2026

Refinement of the Pathogenic T Cell Receptor Motif Suggests Type 17 CD8+ T Cells Initiate HLA-B*27-associated Autoimmunity

Human leukocyte antigen B*27 (HLA-B*27) is a major risk factor for autoimmune diseases such as axial spondyloarthritis (axSpA), acute anterior uveitis (AAU), and psoriatic arthritis (PsA). HLA-B*27 presents bacterial and self-antigens to disease-associated CD8+ T cells, however, how this leads to a pathogenic IL-17-med...

Isabel Risch, Qin-Ping Wu, Rahul Devkota et al. · 0 citations
Aug 2026

T Cell Interferon and Cytotoxic Pathways in Axial Spondyloarthritis: Relationship to Secukinumab Response Profiles

Our study aims to define the difference in granzyme (GZMs) expression in axial spondyloarthritis (axSpA) patients that predisposes secukinumab treatment response. Secukinumab treatment response, as determined using BASDAI50 scoring at week 24, stratified patients into responders (SEC-R) and nonresponders (SE...

Addison Pacheco, Zoya Qaiyum, Melissa Lim et al. · 0 citations
Aug 2026

STK17B/DRAK2 in Axial Spondyloarthritis: Expression Patterns in Blood and Tissue

Pre-biologic STK17B expression was higher among patients who were later identified as non-responders to IL-17i compared with responders, suggesting that DRAK2 upregulation contributes to axSpA-related inflammation and to treatment resistance, warranting further mechanistic investigation.

P. Remalante-Rayco, S. Jo, Addison Pacheco et al. · 0 citations

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